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• 07:12, 28 December 2025 MelvaA1875 talk contribs created page If You Ask People About GLP-1 This Is What They Answer (Created page with "<br> Stimulation of CNS GLP-1 increases sympathetic nerve activity in lean mice, leading to a stimulation of β2-AR and NOR-1 and thereby decreasing the expression of some key enzymes promoting lipid deposition. Contrary, in DIO mice, CNS GLP-1 loses its capacity to act on WAT, indicating that obesity induces an adipocyte resistance to CNS GLP-1. Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-i...")